The Rione Sanità district in the northern part of Naples is home to three catacombs that were burrowed into Capodimonte hill. In an area that was outside the city walls at the time, they date to the paleo-Christian period (1st to the early 4th century BCE). The final resting place of saints, martyrs and bishops, these catacombs are perhaps the most important remains from early Christianity in Naples.

The Catacombs of San Severo are dedicated to the Neapolitan Bishop Saint Severus (346 – 410) who is credited with moving San Gennaro from Pozzuoli to the Catacombs of San Gennaro. Little remains today of this church in which San Severo chose to be buried and his remains were moved to the Basilica San Giorgio Maggiore in the 9th century.